منابع مشابه
ECM communicates with MMP
In This Issue In This Issue cGMP steers axons home n page 489, Schmidt et al. identify a second messenger that helps to steer growth cones. Without this cGMP-directed guidance system, sensory axons lose their way during development. Axonal pathfinding and cyclic nucleotide second messengers have been linked by recent in vitro studies showing that cGMP protects growth cones from collapse induced...
متن کاملThe motor cortex communicates with the kidney.
We used retrograde transneuronal transport of rabies virus from the rat kidney to identify the areas of the cerebral cortex that are potential sources of central commands for the neural regulation of this organ. Our results indicate that multiple motor and nonmotor areas of the cerebral cortex contain output neurons that indirectly influence kidney function. These cortical areas include the pri...
متن کاملTouch communicates distinct emotions.
The study of emotional signaling has focused almost exclusively on the face and voice. In 2 studies, the authors investigated whether people can identify emotions from the experience of being touched by a stranger on the arm (without seeing the touch). In the 3rd study, they investigated whether observers can identify emotions from watching someone being touched on the arm. Two kinds of evidenc...
متن کاملECM signals ECM degradation
W hen Caroline Damsky moved her lab to the University of California, San Francisco, in 1985, she knew she would have an instant colleague in Zena Werb. There was a natural connection between their work. That connection would be refl ected in their discoveries, which delineated an integrin-mediated pathway from the extracellular matrix (ECM) outside the cell to the internal, gene-expressing life...
متن کاملEstablishment and Validation of Computational Model for MT1-MMP Dependent ECM Degradation and Intervention Strategies
MT1-MMP is a potent invasion-promoting membrane protease employed by aggressive cancer cells. MT1-MMP localizes preferentially at membrane protrusions called invadopodia where it plays a central role in degradation of the surrounding extracellular matrix (ECM). Previous reports suggested a role for a continuous supply of MT1-MMP in ECM degradation. However, the turnover rate of MT1-MMP and the ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1593iti4